Which of the Following Statements Is Inaccurate Regarding the Complement

Which of the following statements is inaccurate regarding the complement proteins?

A) They are blood plasma proteins.
B) Some form the membrane attack complex, which forms a hole in the bacterial plasma membrane.
C) They may amplify the inflammatory response by attracting phagocytes to the site of the infection.
D) They may bind to pathogens already coated with antibodies, ensuring they are phagocytized.
E) Many proteins must be independently activated in order to have a significant impact on the immune response.