A patient has a white cell count of 12.6 × 10⁹/L,hematocrit of 28%,and platelet count of 27 × 10⁹/L.Examination of a Wright-stained blood film reveals that almost all of the white cells in peripheral blood are blasts;the bone marrow is hypercellular with very little fat and is packed with blasts.Flow cytometry is performed on the peripheral blood cells,and a large cluster of cells is present that mark with CD20 and have monoclonal k light chains present on their surface.This patient has

Question

Quizplus · Accepted Answer

Mature B lymphocytes express CD20 and either k or l light chains on their surface.In a B-cell reactive process,a mixture of k and l light chain positivity will be observed.The expression of only one light chain on the surface of a population of B cells is called monoclonality and is indicative of a phenotypically mature B-cell malignancy.

A Patient Has a White Cell Count of 12