A clinical laboratory receives a new lot of PTT reagent,so clinical laboratory scientists in the laboratory need to establish the heparin therapeutic range for this new reagent lot.How should this be done?

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Accrediting agencies for clinical laboratories require that the PTT heparin therapeutic range be determined using samples from patients who are receiving heparin therapeutically;they cannot be receiving simultaneous warfarin therapy (thus their PT must be normal).Both a chromogenic anti-Xa assay and PTT are performed on each patient sample,and the paired results are plotted in a linear graph.The range that corresponds to 0.3 to 0.7 chromogenic anti-Xa is the therapeutic range.

A Clinical Laboratory Receives a New Lot of PTT Reagent,so