The inner lining, or submucosa, of the digestive tract consists of a layer of loose connective tissue covered by an epithelium moistened by glandular secretions. The submucosal epithelium may be stratified or simple, depending on the location and the stresses involved.

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The submucosa of the digestive tract is a layer of dense irregular connective tissue that supports the mucosa, contains blood vessels, lymphatics, and nerves, but it does not have an epithelial layer. The mucosa is the layer that includes the epithelium.

The Inner Lining, or Submucosa, of the Digestive Tract Consists