The Underlying Molecular Defect in Oral Squamous Cell Carcinoma Has

The underlying molecular defect in oral squamous cell carcinoma has been linked to which of the following?

A) Amplification of genes associated with acceleration of cell cycle
B) Mutations of the p53 gene
C) Increased cell survival by alteration of apoptosis-associated protein expression
D) Increased cell motility through alteration of keratinocyte integrins and extracellular matrix protein expression
E) All the above