A patient with a secondary oral herpes simplex infection would:

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Secondary oral herpes simplex infection implies that the patient has been previously exposed to the virus, hence they would have circulating antibodies (eliminating A). The infection is typically painful (eliminating B). Positive basement membrane immunofluorescence on direct tissue examination is not characteristic of herpes simplex infections, which are diagnosed based on clinical presentation and confirmed with PCR or viral culture (eliminating C). While fever, malaise, and arthralgia can be associated with primary infection, they are not as commonly associated with secondary outbreaks, which are generally less severe (eliminating D).

A Patient with a Secondary Oral Herpes Simplex Infection Would