Negative effects on tooth development due to chromosomal abnormalities are caused by:

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Malformations are caused by genetic factors,which include abnormalities in the chromosomes.
Environmental factors known as teratogens can have a negative effect on tooth development.Some examples of teratogens are infections,drugs,and radiation exposure.
The rubella virus can cause congenital malformations,but it is simply one example of an environmental factor that can be responsible for negative effects on tooth development.
Ionizing radiation is a form of radiation,but it is simply one example of an environmental factor that can be responsible for negative effects on tooth development.

Negative Effects on Tooth Development Due to Chromosomal Abnormalities Are