Parathyroid hormone (PTH)causes
A)increased RANKL and decreased OPG.
B)PTH has no effect on RANKL and OPG.
C)increased RANKL and increased OPG.
D)decreased RANKL and decreased OPG.
E)decreased RANKL and increased OPG.

Question

Quizplus · Accepted Answer

Parathyroid hormone (PTH) increases the expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteoblasts, which promotes osteoclast differentiation and bone resorption. PTH also decreases the expression of osteoprotegerin (OPG), which is a decoy receptor for RANKL and inhibits its activity. Therefore, the net effect of PTH is increased RANKL and decreased OPG, leading to increased bone resorption.

Parathyroid Hormone (PTH)causes