Absolute medical contraindications to nitrous oxide use:

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Absolute medical contraindications to nitrous oxide use do not exist,but certain conditions make it a poor choice for some persons.
No evidence indicates that enough nitrous oxide crosses the placenta to damage the fetus.However,N₂O/O₂ analgesia is usually administered to a pregnant patient only after the first trimester,and only with the permission of her physician.
Nasal obstruction can prevent the patient from obtaining the benefit of nitrous oxide.
Patients with emphysema and multiple sclerosis may have breathing difficulties while receiving N₂O/O₂ sedation.The increased oxygen delivery during administration may lower the stimulus to breathe as often as necessary.

Absolute Medical Contraindications to Nitrous Oxide Use