Current Research into Neurotransmitter Systems Has Produced the 'Permissive' Hypothesis

Current research into neurotransmitter systems has produced the 'permissive' hypothesis, which states that

A) low levels of serotonin are sufficient to explain the aetiology of mood disorders.
B) the noradrenaline system regulates serotonin levels; if noradrenaline is low, depression will occur.
C) when serotonin levels are low, other neurotransmitter systems become dysregulated and contribute to mood irregularities.
D) the absolute levels of neurotransmitters are more significant in mood regulation than the overall balance of the various neurotransmitters.