Considering the pathophysiologic process of osteoporosis,what are the effects of extracellular signal-regulated kinases (ERKs)and receptor activator of nuclear factor kB ligand (RANKL)on osteoblasts and osteoclasts?
A) ERKs increase the life span of osteoclasts, and RANKL decreases the life span of osteoblasts.
B) ERKs and RANKL increase the life span of osteoclasts and decrease the life span of osteoblasts.
C) ERKs and RANKL increase the life span of osteoblasts and decrease the life span of osteoclasts.
D) ERKs increase the life span of osteoblasts, and RANKL decreases the life span of osteoclasts.

Question

Quizplus · Accepted Answer

In addition to ERKs,RANKL is required for the antiapoptotic effect and thus longer life span of osteoclasts.This effect also shortens the life span of the bone-forming cells,or osteoblasts.This process is not true of any of the other options.

Considering the Pathophysiologic Process of Osteoporosis,what Are the Effects of Extracellular