In secondary multiple organ dysfunction syndrome (MODS),what stimulates the normal endothelial cells to change to a proinflammatory state?

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Normal endothelial cells have little interaction with leukocytes except when stimulated by TNF,IL-1,and IL-6.This selection is the only option that accurately describes what stimulates the normal endothelial cells to change to a proinflammatory state.

In Secondary Multiple Organ Dysfunction Syndrome (MODS),what Stimulates the Normal