John C. Calhoun first raised the doctrine of nullification in response to a tariff imposed by the federal government.

Name: John C. Calhoun first raised the doctrine of nullification in response to a tariff imposed by the federal government.
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John C. Calhoun first raised the doctrine of nullification in response to the Tariff of 1828, which he and others in the South viewed as unfairly beneficial to Northern industries at the expense of Southern economies.

John C Calhoun First Raised the Doctrine of Nullification in Response