Many G protein-coupled receptors contain seven transmembrane α-helical domains. If the amino terminus of such a protein is located on the extracellular side of the membrane, where would you expect to find the carboxyl terminus of the protein?

Question

Quizplus · Accepted Answer

Given the structure of G protein-coupled receptors with seven transmembrane domains, if the amino terminus is extracellular, the pattern of alternating in-out transmembrane domains means the carboxyl terminus would be located on the cytosolic side of the plasma membrane.

Many G Protein-Coupled Receptors Contain Seven Transmembrane α-Helical Domains