Many G protein-coupled receptors contain seven transmembrane α-helical domains. If the amino terminus of such a protein is located on the extracellular side of the membrane, where would a coupled G protein most likely interact with this receptor?

Question

Quizplus · Accepted Answer

The G protein typically interacts with the intracellular loops of the receptor, particularly between helices 5 and 6, where the receptor undergoes conformational changes upon ligand binding.

Many G Protein-Coupled Receptors Contain Seven Transmembrane α-Helical Domains