How does the toxin of Vibrio cholerae cause profuse diarrhea?
A) It modifies a G protein involved in regulating salt and water secretion.
B) It modifies adenylyl cyclase and triggers excess formation of cAMP.
C) It signals IP3 to act as a second messenger for the release of calcium.
D) It modifies a ligand-gated ion channel.

Question

Quizplus · Accepted Answer

The toxin of Vibrio cholerae modifies a G protein, which leads to the continuous activation of adenylyl cyclase, resulting in excessive cAMP production. This causes the intestinal cells to secrete large amounts of water and salts into the intestines, leading to profuse diarrhea.

How Does the Toxin of Vibrio Cholerae Cause Profuse Diarrhea