Which of the following best explains why a bone marrow transplant may not be appropriate from a given donor to a given recipient even though they are compatible for blood transfusions?
A) their blood-types may match but major histocompatibility (MHC) proteins may not be a match
B) a blood type match is less stringent than a match required for transplant because blood is more tolerant of change
C) there is only one allele for blood-type, but there are many alleles for bone-marrow type
D) the given donor's MHC class II genes are not expressed in bone marrow

Question

Quizplus · Accepted Answer

A bone marrow transplant requires compatibility beyond just matching blood types, specifically a match in major histocompatibility (MHC) proteins. Blood transfusions are based on blood type compatibility, but bone marrow transplants require a match in the MHC proteins to prevent immune rejection.

Which of the Following Best Explains Why a Bone Marrow