Researchers at a pharmaceutical company are working to develop a new drug that would cause a patient to produce urine that is less concentrated. Which of the following drugs would likely work best to produce this outcome?

Question

Quizplus · Accepted Answer

A drug that opens sodium channels in the ascending limb of the loop of Henle would likely work best to produce less concentrated urine. This is because increasing sodium reabsorption in this part of the nephron would reduce the osmolarity of the surrounding interstitial fluid, thereby decreasing the reabsorption of water further down the nephron, leading to more dilute urine.

Researchers at a Pharmaceutical Company Are Working to Develop a New