The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis and is inhibited by high levels of which of the following molecules?

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Phosphofructokinase (PFK) is a key regulatory enzyme in glycolysis, and its activity is inhibited by high levels of ATP and citrate. ATP acts as a signal of high energy status, reducing the enzyme's activity to prevent unnecessary glucose breakdown when energy is plentiful. Citrate, an intermediate in the citric acid cycle, signals that biosynthetic precursors are abundant, also leading to inhibition of PFK and thus glycolysis.

The Enzyme Phosphofructokinase (PFK) Catalyzes a Key Step in Glycolysis