The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Dogs affected with this disorder most likely display which of the following symptoms?
A) They die as embryos.
B) They constantly have low blood sugar.
C) They are lethargic and readily tire from exercise.
D) They carry out elevated levels of oxidative phosphorylation.

Question

Quizplus · Accepted Answer

Phosphofructokinase (PFK) is crucial for glycolysis, the pathway that breaks down glucose for energy. Dogs with PFK deficiency cannot efficiently produce energy from glucose, leading to lethargy and exercise intolerance.

The Enzyme Phosphofructokinase (PFK) Catalyzes a Key Step in Glycolysis