The topical drug ________ inhibits protein synthesis in Gram positive bacteria by preventing loading of isoleucine onto tRNA.

Question

Quizplus · Accepted Answer

Mupirocin inhibits bacterial protein synthesis by binding to isoleucyl-tRNA synthetase, an enzyme responsible for loading isoleucine onto tRNA. This prevents the incorporation of isoleucine into newly synthesized proteins, thereby inhibiting bacterial growth. The drug is primarily used topically to treat skin infections caused by Gram positive bacteria, such as impetigo, and is not effective against Gram negative bacteria.

The Topical Drug ________ Inhibits Protein Synthesis in Gram Positive