A between-subjects design with human participants can be less sensitive than a between-subjects design with animals because it is easier to match animal participants on relevant variables than it is to match human participants.

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In a between-subjects design, matching participants on relevant variables is crucial for reducing variability and increasing the sensitivity of the experiment to detect differences between groups. It is generally easier to control or match for variables such as age, genetic background, and environmental conditions in animal participants than in human participants, where genetic diversity, environmental influences, and ethical considerations introduce more variability and make matching more challenging.

A Between-Subjects Design with Human Participants Can Be Less Sensitive