Plasma phenobarbital concentrations achieved with any given dose vary considerably from patient to patient. Therefore, the only way to ensure a dosage regimen is adequate is to

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Checking blood levels of phenobarbital is the most direct and reliable method to ensure that the dosage regimen is adequate, as it directly measures the concentration of the drug in the patient's system. This allows for adjustments to be made based on the specific needs and response of the individual patient.

Plasma Phenobarbital Concentrations Achieved with Any Given Dose Vary Considerably