A patient requires long term treatment with a medication to control her seizures. The medication is available in several forms, and although the client is relatively inexperienced with treating animals is willing to be trained by a technician for home dosing. This drug is known to have a high first-pass effect. Which of the routes should be avoided if possible to administer this drug?

Question

Quizplus · Accepted Answer

The first-pass effect refers to the significant metabolism of a drug within the liver after it is absorbed from the gastrointestinal tract but before it reaches systemic circulation. Therefore, oral (PO) administration should be avoided for drugs with a high first-pass effect to ensure more of the drug reaches systemic circulation without being metabolized.

A Patient Requires Long Term Treatment with a Medication to Control