Poisoning with organophosphate (OP) insecticides is often correlated with signs of increased parasympathetic nervous system activity, such as excessive salivation, constricted pupils, vomiting and diarrhea, and the antidote of choice for such a toxicity is atropine. A specific neurotransmitter is implicated for the clinical signs mentioned when OPs are ingested over time. Name the neurotransmitter.

Question

Quizplus · Accepted Answer

Organophosphate poisoning leads to an accumulation of acetylcholine due to the inhibition of acetylcholinesterase, causing overstimulation of the parasympathetic nervous system, which is responsible for the symptoms observed.

Poisoning with Organophosphate (OP) Insecticides Is Often Correlated with Signs