The secretion of vasopressin increases if the extracellular fluid becomes hypertonic.

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When the extracellular fluid becomes hypertonic, which means the concentration of solutes outside the cells is higher than the concentration inside the cells, the hypothalamus in the brain detects this change and signals the posterior pituitary gland to secrete more vasopressin, also known as antidiuretic hormone (ADH). Vasopressin helps the kidneys retain water, reducing the concentration of solutes in the blood and restoring fluid balance in the body.

The Secretion of Vasopressin Increases If the Extracellular Fluid Becomes