SSRIs have largely replaced that produced the same neurotransmitter effect but had more side effects.

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Tricyclic antidepressants were commonly prescribed before SSRIs became available. While tricyclic antidepressants also target neurotransmitters like serotonin, norepinephrine, and dopamine, they have more side effects such as dry mouth, blurry vision, constipation, and urinary retention. SSRIs were found to be equally effective in treating depression with fewer side effects, making them more popular.

SSRIs Have Largely Replaced That Produced the Same Neurotransmitter Effect