If lithium is not effective alone, then may also be prescribed.

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Divalproex (also known as valproic acid or Depakote) is often used as an alternative to lithium or in combination with lithium for the treatment of bipolar disorder. It has been shown to be effective in stabilizing mood and preventing relapse in some patients who do not respond to lithium therapy alone. Paxil and Zoloft are antidepressants and would not be typically used as a first-line treatment for bipolar disorder. Lithium II is not a recognized medication.

If Lithium Is Not Effective Alone, Then May Also Be