An enzyme is thought to optimize the fit between substrates by restraining and stretching or squeezing them into certain shapes and moving them to the transition state, as described by the ____ model of enzyme activity.
A) lock and key
B) induced-fit
C) template
D) activation
E) conformational

Question

An enzyme is thought to optimize the fit between substrates by restraining and stretching or squeezing them into certain shapes and moving them to the transition state, as described by the ____ model of enzyme activity.
A) ​lock and key
B) ​induced-fit
C) ​template
D) ​activation
E) conformational​

Quizplus · Accepted Answer

The induced-fit model of enzyme activity describes how enzymes optimize the fit between substrates by restraining and stretching or squeezing them into certain shapes and moving them to the transition state. In contrast, the lock and key model proposes that the enzyme active site is already in the perfect shape to fit the substrate, without any need for modification. The template model suggests that the enzyme acts as a physical mold that shapes the substrate as it binds. The activation model describes how enzymes lower the activation energy required for a reaction to occur by providing an alternative pathway. The conformational model refers to changes in the shape of the enzyme itself, rather than the substrate.

An Enzyme Is Thought to Optimize the Fit Between Substrates