Which of the following causes DNA to wrap tightly around histones essentially preventing transcription?

Question

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Methylation causes DNA to wrap tightly around histones essentially preventing transcription. This is because the addition of methyl groups to DNA can attract proteins that promote compaction of the chromatin structure, making it more difficult for transcription factors and RNA polymerase to access the DNA and initiate transcription.

Which of the Following Causes DNA to Wrap Tightly Around