When did the "irrepressible conflict" over slavery in the territories begin?

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The "irrepressible conflict" over slavery in the territories began in the late 1840s with the debate over whether newly acquired territories from the Mexican-American War would allow slavery or not. This led to the Compromise of 1850, which only temporarily resolved the issue and set the stage for further conflict in the years leading up to the Civil War.

When Did the "Irrepressible Conflict" Over Slavery in the Territories