What two criteria generally distinguish drug abuse from drug use?

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Drug abuse is generally characterized by the increased risk of harm, such as overdose or addiction, and the interference with normal, daily responsibilities such as work, school, or relationships. Drug use, on the other hand, may be occasional or controlled and does not typically result in these negative consequences. While criteria such as tolerance and withdrawal may also be present in cases of drug abuse, they are not necessarily required for the distinction between drug use and abuse.

What Two Criteria Generally Distinguish Drug Abuse from Drug Use