The main issue that led to the "Missouri Compromise" was

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The Missouri Compromise was a legislative agreement passed in 1820 to settle the issue of adding new states to the Union and maintain a balance between free states and slave states. This issue arose because of the growing tension between the North and South over the expansion of slavery into new territories. The compromise allowed Missouri to enter the Union as a slave state and Maine as a free state, balancing the number of free and slave states in the country. It also prohibited slavery in all new states north of the 36 30' parallel, with the exception of Missouri.

The Main Issue That Led to the "Missouri Compromise" Was