An irreversible inhibitor is one that

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Irreversible inhibitors bind covalently to the enzyme, forming a permanent bond that cannot be broken by normal physiological conditions. This is typically achieved through the formation of reactive intermediates that covalently modify functional groups within the enzyme's active site. As a result, irreversible inhibitors can cause permanent enzyme inactivation and are often used in the development of drugs and pesticides.

An Irreversible Inhibitor Is One That