What is the order of decreasing reactivity towards nucleophilic acyl substitution for the carboxylic acid derivatives? (most reactive first)

Question

Quizplus · Accepted Answer

The order of decreasing reactivity towards nucleophilic acyl substitution for the carboxylic acid derivatives is as follows:
I. Acid halides (most reactive)
II. Anhydrides
III. Esters
IV. Amides (least reactive)

Therefore, the correct order is I, III, IV, II as given in option B.

What Is the Order of Decreasing Reactivity Towards Nucleophilic Acyl