During the final portion of prolonged, intense exercise when muscle glycogen is low, ingesting fructose does not improve performance because fructose is:

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During prolonged, intense exercise, muscle glycogen may become depleted. Ingesting fructose will not improve performance at this point because it is converted to glucose too slowly to be able to provide immediate energy for the muscles. Glucose is the preferred source of fuel for muscle cells during exercise. While fructose can be converted to glucose by the liver, the process is slower and may not provide enough energy to improve performance during the final portion of intense exercise.

During the Final Portion of Prolonged, Intense Exercise When Muscle