Which of the Following Is Tru Regarding Erythropoietin

Which of the following is tru regarding erythropoietin?

A) Erythropoietin is mainly secreted by the liver
B) Injection of erythropoietin leads to a rapid increase in the number of circulating red blood cells within the next 48 hours
C) Excessive exposure to x-rays with destruction of the bone marrow leads to an increased erythropoietin secretion
D) Erythropoietin also acts on the spleen by decreasing red blood cell destruction