An apparently healthy 12-year-old boy dies during a minor surgical procedure while under general anesthesia. An uncle had also died during a surgical procedure. Results of a halothane contracture test indicate that the child had malignant hyperthermia. Malignant hypothermia crisis is associated with which of the following?

Question

Quizplus · Accepted Answer

Malignant hyperthermia crisis is associated with defective ryanodine receptors in skeletal muscles, leading to uncontrolled release of calcium ions and subsequent hypermetabolic state. This results in increased anaerobic metabolism, CO₂ production, and lactic acid production by muscles, as well as increased usage of adenosine triphosphate in muscles, leading to hyperthermia, acidosis, muscle rigidity, and potential organ failure.

An Apparently Healthy 12-Year-Old Boy Dies During a Minor Surgical