The abnormal cleavage of mannose residues during the posttranslational processing of glycoproteins has been shown to result in the development of a lupus-like autoimmune disease in mice. The abnormal cleavage is due to a mutation of the enzyme $\alpha$-mannosidase II. Based on your understanding of the processing of membrane proteins, you would predict this enzyme to be localized to which of the following?
A)Nucleus
B)Cytosol
C)Golgi apparatus
D)Lysosomes
E)Peroxisomes

Question

Quizplus · Accepted Answer

Mannosidase II is responsible for processing of N-linked glycoproteins in the Golgi apparatus, specifically in the cis-Golgi network and medial Golgi cisternae. Therefore, it is most likely localized in the Golgi apparatus.

The Abnormal Cleavage of Mannose Residues During the Posttranslational Processing α\alphaα

The Abnormal Cleavage of Mannose Residues During the Posttranslational Processing $\alpha$