During starvation, red blood cells continue to rely solely on glucose as a substrate for ATP production

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During starvation, the body turns to glycogen breakdown and then to gluconeogenesis to produce glucose for energy. While some tissues can use alternative substrates for ATP production, red blood cells rely solely on glucose as they lack organelles and are unable to carry out oxidative phosphorylation in the mitochondria.

During Starvation, Red Blood Cells Continue to Rely Solely on Glucose