High fever,headache,extreme fatigue,and a rash on the face that progresses to fluid- and pus-filled sores before crusting over and healing are signs and symptoms consistent with infection with

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The signs and symptoms described are characteristic of a poxvirus infection, specifically smallpox. Smallpox is caused by the variola virus, which presents with high fever, headache, extreme fatigue, and a rash on the face that progresses to fluid- and pus-filled sores before crusting over and healing. Adenovirus, herpesvirus, papillomavirus, and polyomavirus do not typically cause these specific symptoms.

High Fever,headache,extreme Fatigue,and a Rash on the Face That Progresses