A polyubiquitin chain has been attached to a protein. The ubiquitin molecules are linked together via isopeptide bonds between Lys48 of one molecule and the carboxyl end of the next one. This protein is expected to …
A) be a part of chromatin.
B) undergo proteasomal degradation.
C) be involved in DNA repair.
D) be targeted to endocytic vesicles.
E) None of the above.

Question

Quizplus · Accepted Answer

A polyubiquitin chain with Lys48 linkages generally targets the attached protein to the proteasome for degradation. However, other forms of modification by ubiquitin or related proteins can be involved in a variety of different processes.

A Polyubiquitin Chain Has Been Attached to a Protein