A protein is drawn in the following simplified diagram undergoing a set of covalent modifications including the addition of a chain of ubiquitin protein monomers (U) to one of its lysine side chains, a phosphate moiety (P) to its tyrosine side chain, and a lipid farnesyl (F) to its cysteine side chain. Indicate the order of these modifications (1 to 3) in the diagram. Your answer would be a three-letter string composed of letters F, U, and P only, e.g. PFU.

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A protein is drawn in the following simplified diagram undergoing a set of covalent modifications including the addition of a chain of ubiquitin protein monomers (U) to one of its lysine side chains, a phosphate moiety (P) to its tyrosine side chain, and a lipid farnesyl (F) to its cysteine side chain. Indicate the order of these modifications (1 to 3) in the diagram. Your answer would be a three-letter string composed of letters F, U, and P only, e.g. PFU.
  
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Quizplus · Accepted Answer

Attachment of lipid compounds such as the farnesyl group to a protein causes it to become membrane-associated. At the right time, a specific phosphorylation can result in recognition of the protein by certain partners, which in this case target the protein for degradation by polyubiquitin addition.
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A Protein Is Drawn in the Following Simplified Diagram Undergoing