Dukkha, one of the Three Characteristics of Existence as taught by the Buddha, means:

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Dukkha refers to the fundamental unsatisfactoriness or suffering that is an inherent part of the human condition, according to the Buddha's teachings. It refers to the pain or suffering that is experienced due to the impermanence and constant change of things, as well as the unsatisfied desires and cravings that arise from our attachment to those things. Dukkha is most commonly translated as "suffering" or "unsatisfactoriness." It refers to the inherent difficulties and challenges of existence, such as sickness, old age, and death, as well as the existential angst and dissatisfaction that arises from our constant striving for happiness and security in a world that is inherently unstable and unpredictable.

Dukkha, One of the Three Characteristics of Existence as Taught