The eukaryotic chromosomes are organized inside the nucleus with a huge compaction ratio of several-thousand-fold. What is responsible for such a tight packaging?

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Quizplus · Accepted Answer

The various chromatin proteins, including histone and non-histone proteins, wrap and fold the DNA to achieve an astonishing compaction ratio. The nuclear envelope and the nuclear matrix are dispensable for this effect, as evident by the high compaction seen in mitotic chromosomes when the nucleus is disassembled.

The Eukaryotic Chromosomes Are Organized Inside the Nucleus with a Huge