The Acetylation of Lysines on the Histone Tails …

The acetylation of lysines on the histone tails …

A) loosens the chromatin structure because it adds positive charges to the histone.
B) recruits the heterochromatin protein HP1, resulting in the establishment of heterochromatin.
C) can be performed on methylated lysines only after they are first demethylated.
D) is sufficient for the formation of an open chromatin structure.
E) is a covalent modification and is thus irreversible.