Indicate true (T) and false (F) statements below regarding human genetic variations. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTF.
( ) The genomes of two randomly chosen humans are expected to be identical with respect to at least 99.99% of the nucleotides.
( ) Copy number variations can contain genes.
( ) If the frequency of a point mutation in a population is only 0.1%, with no mutation at this site in the rest of the population, then the variation is NOT considered to constitute a single-nucleotide polymorphism.
( ) Most of the common genetic variants in the current human population could have been present in a human ancestral population of only about 10,000 individuals.

Question

Indicate true (T) and false (F) statements below regarding human genetic variations. Your answer would be a four-letter string composed of letters T and F only, e.g. TFTF.
( )	The genomes of two randomly chosen humans are expected to be identical with respect to at least 99.99% of the nucleotides.
( ) 	Copy number variations can contain genes.
( )	If the frequency of a point mutation in a population is only 0.1%, with no mutation at this site in the rest of the population, then the variation is NOT considered to constitute a single-nucleotide polymorphism.
( )	Most of the common genetic variants in the current human population could have been present in a human ancestral population of only about 10,000 individuals.

Quizplus · Accepted Answer

A number of variations-such as scattered rare mutations and abnormalities, single-nucleotide polymorphisms, simple tandem repeat expansions [such as those of the (CA)n repeats], and copy number variations-makes each two human individuals of the same sex different in, at least, about 1 in every 1000 nucleotides of their genomes; therefore, 99.99% identity is an overestimation. Nearly half of the copy number variations contain genes. For a variation at a nucleotide position to be considered a single-nucleotide polymorphism, it must be common enough such that the probability that two individuals have a different nucleotide at this position is at least 1%. It is estimated that the current pattern of human genetic variation was mostly in place when our ancestral population size was about 10,000.

Indicate True (T) and False (F) Statements Below Regarding Human