Indicate true (T) and false (F) descriptions below regarding the nucleotide excision repair pathway. Your answer would be a four-letter string composed of letters T and F only, e.g. FFFF.
( ) It involves recognition of distortions in the DNA double helix rather than specific base changes.
( ) It involves endonucleolytic cleavage and helicase-mediated strand removal.
( ) It involves cleavage by the AP endonuclease.
( ) It is coupled to the DNA transcription machinery of the cell.

Question

Indicate true (T) and false (F) descriptions below regarding the nucleotide excision repair pathway. Your answer would be a four-letter string composed of letters T and F only, e.g. FFFF.
( )	It involves recognition of distortions in the DNA double helix rather than specific base changes.
( )	It involves endonucleolytic cleavage and helicase-mediated strand removal.
( )	It involves cleavage by the AP endonuclease.
( )	It is coupled to the DNA transcription machinery of the cell.

Quizplus · Accepted Answer

In nucleotide excision repair, a multienzyme complex recognizes DNA double-helix distortions caused by damage. This pathway involves cutting the strand containing the damage at two positions flanking the damage. A helicase is also recruited and catalyzes strand removal. This pathway is also linked to the transcription machinery.

Indicate True (T) and False (F) Descriptions Below Regarding the Nucleotide