In the following schematic diagram of a region of a mammalian genome, genes A to D (triangles) are located in between a number of insulator elements (white squares) and barrier sequences (black squares). If the cis-regulatory sequence (oval) is bound by an abundant repressor protein, which gene would you expect to be expressed at a higher rate in this cell?

Question

In the following schematic diagram of a region of a mammalian genome, genes A to D (triangles) are located in between a number of insulator elements (white squares) and barrier sequences (black squares). If the cis-regulatory sequence (oval) is bound by an abundant repressor protein, which gene would you expect to be expressed at a higher rate in this cell? In the following schematic diagram of a region of a mammalian genome, genes A to D (triangles) are located in between a number of insulator elements (white squares) and barrier sequences (black squares). If the cis-regulatory sequence (oval) is bound by an abundant repressor protein, which gene would you expect to be expressed at a higher rate in this cell?

Quizplus · Accepted Answer

Gene D is not protected from heterochromatin expansion by any barrier sequence, while genes A and B are repressed by the cis-regulatory element bound to a repressor. Gene C, however, is not under these repressive effects, thanks to its flanking insulator elements and barrier sequences.

In the Following Schematic Diagram of a Region of a Mammalian