Which of the following is NOT a likely ER signal sequence recognized by the signal-recognition particle? All sequences are written with their N-terminus on the left.
A) Met-Lys-Leu-Ser-Leu-Val-Ala-Ala-Met-Leu-Leu-Leu-Leu-Ser-Ala-Ala-Arg-Ala
B) Met-Glu-Met-Phe-Gln-Gly-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Leu-Ser-Met-Gly-Gly-Thr-Trp-Ala
C) Met-Lys-Ala-Lys-Leu-Leu-Val-Leu-Leu-Tyr-Ala-Phe-Val-Ala-Gly-Asn
D) Met-Met-Ala-Ala-Gly-Pro-Arg-Thr-Ser-Leu-Leu-Leu-Ala-Phe-Ala-Leu-Leu-Cys-Leu-Pro-Trp-Thr-Gln-Val-Val
E) Met-Leu-Ser-Leu-Arg-Gln-Ser-Ile-Arg-Phe-Phe-Lys-Pro-Ala-Thr-Arg-Thr-Leu-Ser-Ser-Arg-Tyr-Leu

Question

Quizplus · Accepted Answer

Note the presence of a positively charged residue (arginine or lysine) at regular intervals in sequence E, which places these residues on one side of an amphiphilic helix, which is part of a protein destined for mitochondria. In the endoplasmic reticulum signal sequences, the uninterrupted hydrophobic core is usually preceded immediately by positively charged residues.

Which of the Following Is NOT a Likely ER Signal